Oxford University’s Engineering Science Department and the Oxford Suzhou Centre for Advanced Research (OSCAR) have developed a rapid testing technology for the corona virus.

The new test is much faster and does not need a complicated instrument.  Previous viral RNA tests took 1.5 to 2 hours to give a result. The research team has developed a new test, based on a technique which is capable of giving results in just half an hour – over three times faster than the current method.

‘The beauty of this new test lies in the design of the viral detection that can specifically recognise SARS-CoV-2 (COVID-19) RNA and RNA fragments,” says Prof Wei Huang, “the test has built-in checks to prevent false positives or negatives and the results have been highly accurate.’

Additionally, the technology is very sensitive.  This means that patients in early stages of infection may be identified sooner, potentially helping to reduce the spread of the coronavirus SARS-CoV-2 (COVID-19).  The technology only requires a simple heat-block which maintains a constant temperature for RNA reverse transcription and DNA amplification, and the results can be read by the naked eye. This makes it potentially useful in rural area or community healthcare centres.

The technology has been validated with real clinical samples at Shenzhen Luohou People’s Hospital in China. Shenzhen Luohu People’s Hospital has applied the rapid detection kits on 16 clinic samples, including 8 positives and 8 negatives, which have been confirmed by conventional RT-PCR methods and other clinical evidence. The test results using the rapid detection kits were all successful.

The Oxford scientists are now working to develop an integrated device so that the test can be used at clinics, airports, or even for home use.

The project was initiated by Oxford Suzhou Centre for Advanced Research (OSCAR), a University of Oxford centre in Suzhou Industrial Park.  The experiments to develop the technology were performed in the Department of Engineering Science at the University of Oxford.